[1]常思佳,邹晓英,庄姮.Notch信号通路与细胞老化的关系[J].牙体牙髓牙周病学杂志,2011,21(07):412-414.
 CHANG Si-jia,ZOU Xiao-ying,ZHUANG Heng,et al.The relationship between Notch signaling pathway and cell senescence[J].Chinese journal of conservative dentistry,2011,21(07):412-414.
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Notch信号通路与细胞老化的关系
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《牙体牙髓牙周病学杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
21
期数:
2011年07期
页码:
412-414
栏目:
综述
出版日期:
2011-07-31

文章信息/Info

Title:
The relationship between Notch signaling pathway and cell senescence
作者:
常思佳 邹晓英 庄姮
北京大学口腔医学院口腔医院牙体牙髓科, 北京 100081
Author(s):
CHANG Si-jia ZOU Xiao-ying ZHUANG Heng YUE Lin
Department of Cariology and Endodontology, Peking University  School and Hospital of Stomatology, Beijing 100081, China
关键词:
[关键词] 细胞 老化 Notch
Keywords:
[Key words] cell senescence Notch
分类号:
R788.2
文献标志码:
A
摘要:
[摘要]Notch信号通路是一种高度进化保守的信号通路,它通过受体配体的相互作用转导细胞信号,可影响从无脊椎动物到哺乳动物等多个物种的发育过程,调节细胞的定向分化、组织和器官的发育。近年来的研究,发现Notch信号通路在细胞的老化过程中也起着重要作用, 抑制此信号通路可导致细胞在形态、代谢相关酶水平以及基因水平上均产生与正常细胞不同的表现。该文就Notch信号通路与细胞老化关系的研究作一综述。
Abstract:
[Abstract]The Notch signaling pathway is a highly conservative transduction system which consists of receptors, ligands and DNA-binding protein in the nucleus. Signas induced by ligand binding are transmitted at the intracellular part of the receptor, in a process involving interactions with cytoplasmic and nuclear proteins. And Notch signaling is involved in phenomena as diverse as differentiation, apoptosis and cell proliferation, thus controlling organ formation and morphogenesis. Recent studies show that Notch signaling pathway plays an important role in the senescence of cells. Inhibition of this pathway would result in changes of cell morphology, proliferation ability and expression level of associated genes.
更新日期/Last Update: 2011-07-30