[1]宋玮,石勇,闫金方.抗菌肽rHBD3对感染根管消毒作用的实验研究[J].牙体牙髓牙周病学杂志,2011,21(07):392-395.
 SONG Wei*,SHI Yong,YAN Jin-fang,et al.Disinfection efficacy of recombinant human beta defensin-3 on infected root canals[J].Chinese journal of conservative dentistry,2011,21(07):392-395.
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抗菌肽rHBD3对感染根管消毒作用的实验研究
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《牙体牙髓牙周病学杂志》[ISSN:1006-6977/CN:61-1281/TN]

卷:
21
期数:
2011年07期
页码:
392-395
栏目:
论著
出版日期:
2011-07-31

文章信息/Info

Title:
Disinfection efficacy of recombinant human beta defensin-3 on infected root canals
作者:
宋玮 石勇 闫金方
1. 广州军区联勤部门诊部, 广东 广州 510080; 2. 省口腔医院, 广东 广州 510280;3.第四军医大学口腔医院,陕西 西安 710032
Author(s):
SONG Wei* SHI Yong YAN Jin-fang TIAN Yu XIAO Ming-zhen
*The Outpatient Service Department Affiliated to the Logistics Department of  [JZ]Guangzhou Military Command, Guangzhou 510080 , China
关键词:
[关键词] 人β防御素-3 感染根管 根管消毒 
Keywords:
[Key words] human beta defensin-3 infected root canal root canal disinfection
分类号:
R780.2
文献标志码:
A
摘要:
[摘要]目的: 验证重组人β防御素-3(rHBD3)对感染根管的消毒作用,为临床应用提供实验依据。方法:制作4只Beagle犬的上下颌第一、二、三恒切牙感染根管模型,按拉丁方设计随机分为FC、氢氧化钙糊剂、rHBD3和空白对照组,分别于根管内消毒前后取样作厌氧和需氧菌培养。结果:X线片证实犬感染根管模型建立成功。消毒前每组所有样本细菌检出率为100% ,消毒后各实验组根管内的细菌,无论厌氧还是需氧菌的检出率均明显减少,消毒前、后差异有统计学意义(P<0.05);同样,各实验组与空白对照组比较均有显著差别(P<0.05);进一步两两比较,FC组、rHBD3组与Ca(OH)2糊剂组也有显著性差别(P<0.05),各实验组相对于需氧和厌氧菌2个菌种之间的消毒无显著性差异(P>0.05)。[HT5”H]结论:rHBD3在感染根管内有明显的抑菌效果。
Abstract:
[Abstract] AIM: To evaluate the disinfection effects of recombinant human beta defensin-3(rHBD3) on the infected root canals. METHODS: The root canals of 48 incisors from 4 dogs were infected and then divided into 4 groups, with 12 incisors in each group. The infected root canals (IRC) were disinfected with FC, Ca (OH)2 pasta and rHBD3 respectively and one group was left untreated as blank control. Before and after disinfection, aerobes and anaerobes were respectively cultured, and the disinfection results of these medicaments were compared and analyzed. RESULTS:X-ray picture confirmed that the animal model of infected root canal was successfully established. Before disinfection, the cultures of aerobes and anaerobes of root canals in each group were all positive. After disinfection, detection rate of aerobic and anaerobic bacteria in experimental groups decreased significantly (P<0.005). And there was significant difference between all experimental groups and blank control group (P<0.005). Further analysis showed that significant differences were found in the disinfection of aerobes and anaerobes between the FC, rHBD3 and Ca(OH)2 pasta groups (P<0.05). However, no significant difference was found between the detection rate of aerobes and anaerobes in experimental groups after disinfection (P>0.05). CONCLUSION:rHBD3 shows a great disinfection efficacy, which has the possibility of application as an intracanal medicament.
更新日期/Last Update: 2011-07-30